- 产品描述
- 产品组分
- 文件资源
- 营销中心
- 注意事项
- FAQ
- 文献追踪
-
For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C20H29N10O22P5 (free acid)
Molecular Weight: 916.37 g/mol (free acid)
Exact Mass: 916.01 g/mol (free acid)
CAS#: 41708-91-2
Purity: ≥ 95 % (HPLC)
Form: solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Specific Ligands:
Ligand for P2Y and P2X receptors:
Agonist at P2Y1 receptor[1,2,3], at P2X1 receptor[4,5], P2X1 - P2X4, P2Y1,2,4,12 receptors[2,4,5] and vascular purinoreceptor P2X[6] -
产品组分
内容
型号
规格 储存温度
AP5A
NU508-01 50ul(10mM)
-20°C AP5A
NU508-02 250ul(10mM)
-20°C 操作手册
1 1 常温
-
营销中心
-
注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
-
Selected References:
[1] Gualix et al. (2014) Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors. Purinergic Signal. 10 (2):349.
[2] Szczepanska-Konkel et al. (2005) Effects of diadenosine polyphosphates on glomerular volume. Br. J. Pharmacol. 144 (8):1109.
[3] Yerxa et al. (2001) P1- (uridine 5')-P4- (2'-deoxycytidine 5')tetraphosphate tetrasodiumsalt a next generation P2Y2 receptor agonist for treatment of cystic fibrosis. J. Pharmacol. Exp. Ther. 302:871.
[4] Zhang et al. (2002) Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301 (2):705.
[5] Allsopp et al. (2013) P2X receptor chimeras highlight roles of amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desentization, and independent regulation of channel transitions. J. Biol. Chem. 288 (29):21412.
[6] Neely et al. (1996) P2X purinoreceptors in the feline pulmonary vascular bed: distribution and selective in vivo pharmacological probes. Am. J. Physiol. 270 (6 Pt 1):L889.
Pintor et al. (1999) Presence of dinucleotide and ATP receptors in human cerebrocortical synaptic terminals. Eur. J. Pharmacol. 366:159.
Wildman et al. (1999) Selectivity of diadenosine polyphosphates for rat P2X receptor subunits. Eur. J. Pharmacol. 367:119.
Jovanovic et al. (1998) Diadenosine 5',5''-P1,P5-pentaphosphate harbors the properties of a signaling molecule in the heart. FEBS Lett. 423:314.
Verspohl et al. (1998) Diadenosine polyphosphates in insulin-secreting cells: interaction with specific receptors and degradation. Diabetes 47:1727.
Delaney et al. (1997) Diadenosine polyphosphates inhibit adenosine kinase activity but decrease levels of endogenous adenosine in rat brain. Eur. J. Pharmacol. 332:35.
Edgecombe et al. (1997) Diadenosine polyphosphate-stimulated gluconeogenesis in isolated rat proximal tubules. Biochem. J. 323:451.
Ogilvie et al. (1996) Adenine dinucleotides: a novel class of signalling molecules. J. Auton. Pharmacol. 16:325.
Schluter et al. (1994) Diadenosine phosphates and the physiological control of blood pressure. Nature 367:186.New Structural and functional insights into Pseudomonas aeruginosa ApaH , a diadenosine tetraphosphatase crucial for bacterial virulence
Gianluca Pistoia, Matteo Cervoni, ..., Giorgio Giardina
Protein Science : A Publication of the Pro… | 2026 Aug 25 | 42640267
Supplementary Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap 3 A Elucidates Its Inhibitory Action on Translation
Doreen Herzog, Jasmin Jansen, ..., Andreas Marx
Journal of the American Chemical Society | 2022 May 06 | 35522782
Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies.
Aliaa Abdelrahman, Vigneshwaran Namasivayam, ..., Christa E Müller
Biochemical pharmacology | 2017 May 09 | 27867013
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.
Dimitri Topalis, Hiroki Kumamoto, ..., Dominique Deville-Bonne
The Febs Journal | 2007 Aug 30 | 17608725
在线留言
如果您对我们的产品感兴趣，请留下您的信息，我们将尽快与您联系，谢谢！
艾维缔官网
艾德官网
B站IVDSHOW
抖音军哥聊表观
视频号艾维缔
小红书艾维缔
快手表观盒子
表观遗传学
联系我们
