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For general laboratory use.
Please centrifuge briefly before opening (volume ≤2 ml).Shipping: shipped on gel packs
Storage Conditions: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.Shelf Life: 12 months after date of delivery
Molecular Formula: C19H27N7O21P4 (free acid)
Molecular Weight: 813.35 g/mol (free acid)
Exact Mass: 813.02 g/mol (free acid)
CAS#: 10527-48-7
Purity: ≥ 95 % (HPLC)
Form: solution in water
Concentration: 10 mM - 11 mM
pH: 7.5 ±0.5
Spectroscopic Properties: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Applications:
Synthesis by mutated enzyme H96G-Fhit[1]
Formation by UTP-glucose-1-phosphate uridyltransferase[2]
Synthesis by pyrococcus furiosus DNA ligase[3]
TUNEL[3]
Effector of Phosphotransferase[4]
Inhibitor of Uridine Kinase[5]
Vasoregulator through P2X1, P2Y2 and P2Y4 receptors[6] -
产品组分
内容
型号
规格 储存温度
AP4U
NU528-01 150ul(10mM)
-20°C AP4U
NU528-02 750ul(10mM)
-20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Selected References:
[1] Huang et al. (2004) Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. J. Am. Chem. Soc. 126 (31):9548.
[2] Guranowski et al. (2004) Uridine 5'-polyphosphates (p4U and p5U) and uridine (5')polyphospho (5')nucleosides (Up (n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae. FEBS Lett. 561 (1-3):83.
[3] Günther et al. (2002) Thermostable Pyrococcus furiosus DNA lgase catalyzes the synthesis of (di)nucleoside polyphosphates. Extremophiles 6 (1):45.
[4] Marques et al. (1998) IMP-GMP 5'-nucleotidase from rat brain: activation by polyphosphates. J. Neurochem. 71 (3):1241.
[5] Cheng et al. (1986) Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs. Mol. Pharmacol. 30 (2):159.
[6] Jankowski et al. (2005) Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Nature Medicine 11 (2):223.Molecular basis for non-canonical transcription initiation from Np 4 A alarmones
Wenqian Duan, Abhishek Kaushik, ..., Alexander Serganov
Nature Chemical Biology | 2025 Oct 15 | 41094128
ApaH decaps Np 4 N-capped RNAs in two alternative orientations.
Ashok Nuthanakanti, Megan Korn, ..., Alexander Serganov
Nature Chemical Biology | 2025 Aug 11 | 40789943
A Novel Protocol for Detection of Senescence and Calcification Markers by Fluorescence Microscopy
Jaqueline Herrmann, Milen Babic, ..., Mirjam Schuchardt
International Journal of Molecular Science… | 2020 May 14 | 32423114
Purification and functional characterization of diadenosine 5',5‴-P(1),P(4)-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium.
Naoko Honda, Hyun Kim, ..., Shigetarou Mori
Protein expression and purification | 2016 Apr 05 | 25940844
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