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AP4(8-碘-G)

AP4(8-碘-G),AP4(8-Iodo-G),AP4(8I-G),P1-(5'-Adenosyl) P4-[5'-(8-iodo)-guanosyl] tetraphosphate, Sodium salt,P1-(5'-腺苷基) P4-[5'-(8-碘)-鸟苷基] 四磷酸钠。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。


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AP4(8-碘-G)


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NU510

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  • For general laboratory use.

    Please centrifuge briefly before opening (volume ≤2 ml).

    Shipping: shipped on gel packs

    Storage Conditions: store at -20 °C
    Short term exposure (up to 1 week cumulative) to ambient temperature possible.

    Shelf Life: 12 months after date of delivery

    Molecular Formula: C20H27IN10O20P4 (free acid)

    Molecular Weight: 978.28 g/mol (free acid)

    Exact Mass: 977.94 g/mol (free acid)

    Purity: ≥ 95 % (HPLC)

    Form: solution in water

    Concentration: 10 mM - 11 mM

    pH: 7.5 ±0.5

    Spectroscopic Properties: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

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    型号

    规格

    储存温度

    AP4(8-碘-G)

    NU510-01

    30ul(10mM)

    -20°C

    AP4(8-碘-G)

    NU510-02

    150ul(10mM)

    -20°C

    操作手册

    1 1

    常温

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    NU510-AP4(8-碘-G)

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  • 注意事项

    保存建议 厂家推荐蓝冰运输。当您收到产品后,按照说明书建议保存于-20°C。

     

  • FAQ

     

  • Selected References:
    [1] Topalis et al. (2007) Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site. FEBS J. 274 (14):3704.
    [2] Hible et al. (2006) Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G. Biochimie 88:1157.
    [3] van der Giet et al. (2001) The critical role of adenosine and guanosine in the affinity of dinucleoside polyphosphates to P (2X)-receptors in the isolated perfused rat kidney. Br. J. Pharmacol. 132 (2):467.
    [4] Lewis et al. (2000)Effects of diadenosine polyphosphates (Ap (n)As) and adenosine polyphospho guanosines (Ap (n)Gs) on rat mesenteric artery P2X receptor ion channels.Br. J. Pharmacol. 129 (1):124.
    [5] van der Giet et al. (2002) Effects of dinucleoside polyphosphates on regulation of coronary vascular tone. Eur. J. Pharmacol. 448 (2-3):207.
    [6] Cinkilic et al. (2001) Selective agonism of group I P2X receptors by dinucleotides dependent on a single adenine moiety. J. Pharmacol. Exp. Ther. 299 (1):131.
    Winward et al. (2010) Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch? Int. J. Biochem. Cell Biol. 42 (7):1174.
    Safrany et al. (2007) Characterisation of a bis (5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogasterInt. J. Biochem. Cell Biol. 39 (5):943.
    Cherfils et al. (2006) Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G. Biochimie 88 (9):1157.
    Gross et al. (2006) Nucleotide-binding domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but not ATP Hydrolysis. J. Biol. Chem. 281 (7):4058.
    Leslie et al. (2002) Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochemistry 3:20.
    Prinz et al. (1999) Binding of nucleotides to guanylate kinase, p21 (ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry. J. Biol. Chem. 274 (50):35337.
    Ortiz et al. (1993) Specific synthesis of adenosine (5')tetraphospho (5')nucleoside and adenosine- (5')oligophospho (5')adenosine (n > 4) catalyzed by firefly luciverase. Eur. J. Biochem. 212 (1):263.
    Feldhaus et al. (1975) Synthetic Inhibitors of Adenylate Kinases in the Assays for ATPases and Phosphokinases. Eur. J. Biochem. 57:197.

    Guanylate Kinase 1 Deficiency: A Novel and Potentially Treatable Mitochondrial DNA Depletion/Deletions Disease.

    Agustin Hidalgo-Gutierrez, Jonathan Shintaku, ..., Michio Hirano

    Annals of Neurology  |  2024 Sep 04  |  39230499

    Purification and functional characterization of diadenosine 5',5‴-P(1),P(4)-tetraphosphate phosphorylases from Mycobacterium smegmatis and Mycobacterium avium.

    Naoko Honda, Hyun Kim, ..., Shigetarou Mori

    Protein expression and purification  |  2016 Apr 05  |  25940844

    Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.

    Dimitri Topalis, Hiroki Kumamoto, ..., Dominique Deville-Bonne

    The Febs Journal  |  2007 Aug 30  |  17608725 

    Characterisation of a bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster.

    Lucinda Winward, William G F Whitfield, ..., Stephen T Safrany

    The international journal of biochemistry …  |  2007 Aug 24  |  17344088

    Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G.

    G Hible, P Daalova, ..., J Cherfils

    Biochimie  |  2007 Jan 23  |  16690197 

    Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but Not ATP Hydrolysis

    Christian H. Gross, Norzehan Abdul-Manan, ..., Jonathan Moore

    Journal of Biological Chemistry  |  2006 Feb 01  

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