抗牛痘A13蛋白[11F7]【兔IgG】

抗牛痘A13蛋白[11F7]【兔IgG】这种嵌合兔抗体是使用原始小鼠IgG2a形式的可变域序列制成的，以提高与现有试剂检测和技术的兼容性。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。

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免疫生物学

目录号

Ab02996-23.0

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牛痘A13蛋白的重组单克隆抗体。使用AbAb的重组平台制造，可变区域（即特异性）来自杂交瘤11F7。

Clone Name:11F7

Published Application(s):Neutralize, SPR, WB, ELISA, IF

Published Species Reactivity:Monkeypox virus, Orthopoxvirus, Vaccinia virus, variola virus

UniProt Accession Number of Target Protein: Q76ZQ4

Alternative Name(s) of Target: VACV; Protein P8; A13L; vaccinia virus; smallpox virus; VACV virion membrane proteins; Virion membrane protein A13; VACWR132
Immunogen: The original antibody was generated by immunizing BALB/c mice with WR strain of live vaccinia virus (VACV).

Specificity: This antibody binds the A13 membrane protein of the vaccinia virus. It recognizes an epitope comprising of a 10-amino acid sequence conserved in all orthopoxviruses, including viriola virus and monkeypox virus.

Application Notes: The original IgG2a version of this antibody bound to recombinant A13 protein expressed in E. coli, MBP conjugated VACV A13 in an ELISA. The original IgG2a antibody bound recombinant A13 proteins from E. coli with an affinity of 3.4 nM as detected by surface plasmon resonance. This antibody was also capable of recognizing a 12-kda protein in a Western blot of VACV-infected HeLa cells. This antibody stained viral factories and virion-size particles in immunofluorescence analysis of infected cells. This antibody was also reported to neutralized VACV mature virions in a plaque reduction assay. Passive immunization of mice with this antibody protected mice against intranasal VACV infection. This antibody generated against smallpox vaccine might contribute to immune protection against orthopoxviruses (PMID: 21810533).

Antibody first published in: Xu et al. An epitope conserved in orthopoxvirus A13 envelope protein is the target of neutralizing and protective antibodies. Virology. 2011 Sep 15; 418(1): 67–73. PMID:21810533
Note on publication: Describes the generation and characterization of this antibody.
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- 抗牛痘A13蛋白[11F7]【兔IgG】

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内容	型号	规格	价格	储存温度
抗牛痘A13蛋白[11F7]【兔IgG】	Ab02996-23.0	200ug	0.00	-20°C
操作手册	1	1		常温

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