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利用脂质立方相（LCP）进行膜蛋白结晶已被证明是一种成功的方法，凭借其类膜天然环境，能从膜蛋白中获得高质量的衍射晶体[1]。
单油酸甘油酯是开展LCP结晶实验的首选脂质。然而，由于脂质的性质决定了LCP的性质，因此通过筛选不同脂质来改变LCP的特性是值得尝试的，尤其是在使用单油酸甘油酯的初始结晶尝试失败后[2,3]。
阴离子磷脂DSPG与单酰基甘油（MAGs）联合使用，可形成热力学稳定的超溶胀双连续立方相，其水通道比传统脂质介观相大五倍，适用于具有大胞外结构域的膜蛋白结晶[4]。
References
[1] Landau and Rosenbusch (1996) Lipidic cubic phases: a novel concept for the crystallization of membrane proteins. PNAS 93:14532.
[2] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3.
[3] Caffrey and Cherezov (2009) Crystallizing Membrane Proteins Using Lipidic Mesophases. Nat Protoc. 4(5):706.
[4] Zabara et al. (2018) Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains. Nat. Commun. 9:544.For research use only.
Description:
Host Lipid for protein crystallization in the Lipidic Cubic Phase (LCP) [1,2]. Used in combination with DSPG to create thermodynamically stable ultraswollen bicontinuous cubic phases with water channels five times larger than traditional lipidic mesophases, suitable for the crystallization of membrane proteins with large extracellular domains [1].
Once opened, use within 6 months. Purge the vial with nitrogen or argon after usage and store at -20°C.Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: C19H36O4
Molecular Weight: 328.43
CAS#: 37515-61-0
Purity: > 99 %
Solubility: Soluble in Hexane
Selected References:
[1] Zabara et al. (2018) Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains. Nat. Commun. 9:544.
[2] Caffrey (2015) A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes. Acta Cryst F 71:3. -
产品组分
内容 型号
规格 储存温度
Monopalmitolein(单棕榈油素)
XLCP102-01 1g
-20°C Monopalmitolein(单棕榈油素)
XLCP102-02 2g
-20°C 操作手册
1 1 常温
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
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