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For research use only.
Description:
Amphipol A8-35 is a short amphipatic polymer that is specifically designed for membrane protein stabilization. The surfactant possesses a very high affinity for the transmembrane surfaces and allows to solubilize membrane proteins in a detergent-free aqueous solution[1].Shipping: shipped at ambient temperature
Storage Conditions: store at -20 °C
Shelf Life: 12 months
Molecular Formula: (C6.2H10.3O1.35N0.65Na0.35)72
Molecular Weight: approx. 9 kDa
CAS#: 326856-53-5
Applications:
Stabilizing agent in Cryo-EM[2-5] and X-ray crystallography[6]Selected References:
[1] Zoonens et al. (2014) Amphipols for Each Season. J Membrane Biol 247:759.
[2] Chen et al. (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:887.
[3] Zubcevic et al. (2016) Cryo-Electron Microscopy of the Trpv2 Ion Channel. Nat Struct Mol Biol 23:180.
[4] Bai et al. (2015) Sampling the conformational space of the catalytic subunit of human gamma-secretase. DOI 10.7554/eLife.11182.
[5] Althoff et al. (2011) Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1. EMBO J 30:4652.
[6] Polovinkin et al. (2014) High-Resolution Structure of a Membrane Protein Transferred from Amphipol to a Lipidic Mesophase. J Membrane Biol 247:997. -
产品组分
内容 型号
规格 储存温度
安菲酚A8-35
XA835-01 50mg
-20°C 安菲酚A8-35
XA835-02 100mg
-20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Bioprocess and biosystems engineering | 2025 Oct 10 | 40751032
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Nature Communications | 2023 Nov 14 | 37963916
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation.
Hasier Eraña, Carlos M Díaz-Domínguez, ..., Joaquín Castilla
Acta Neuropathologica Communications | 2023 Sep 11 | 37679832
The MscS-like channel YnaI has a gating mechanism based on flexible pore helices
Vanessa Judith Flegler, Akiko Rasmussen, ..., Bettina Böttcher
Proceedings of the National Academy of Sci… | 2020 Nov 04 | 33148804
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
Melanie A McDowell, Michael Heimes, ..., Irmgard Sinning
Molecular cell | 2020 Oct 14 | 32910895
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