FAQ

Yang C et. al. (December 2023). Coordinated alternation of DNA methylation and alternative splicing of PBRM1 affect bovine sperm structure and motility. Epigenetics. 18(1):2183339.

Kong X et. al. (April 2023). Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing. Nat Commun. 14(1):2046.

Sha Y et. al. (February 2023). Prediction of the Molecular Subtype of IDH Mutation Combined with MGMT Promoter Methylation in Gliomas via Radiomics Based on Preoperative MRI. Cancers (Basel). 15(5)

Li Z et. al. (July 2022). RNAi-mediated knockdown of Xist improves development of the female buffalo (Bubalus bubalis) nuclear transfer embryos. Theriogenology. 187:27-33.

Han J et. al. (July 2022). IL-7 promoted the development of thymic DN3 cells in aged mice via DNA demethylation of Bcl2 and c-Myc genes. Mol Immunol. 147:21-29.

Qie Y et. al. (June 2022). Low-dose hexavalent chromium(VI) exposure promotes prostate cancer cell proliferation by activating MAGEB2-AR signal pathway. Ecotoxicol Environ Saf. 241:113724.

Yao et. al. (February 2022). Integrated analysis of DNA methylome and RNA transcriptome during high-temperature-induced masculinization in sex-undifferentiated Nile tilapia gonad Aquaculture. 552

Zhang L et. al. (February 2022). Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression. FASEB J. 36(2):e22131.

Liu et. al. (January 2022). Hypermethylation of mitochondrial DNA facilitates bone metastasis of renal cell carcinoma Journal of Cancer. 13(1):304-312.

Gao Y et. al. (November 2021). The contribution of neuropilin-1 in the stability of CD4⁺ CD25⁺ regulatory T cells through the TGF-β1/Smads signaling pathway in the presence of lipopolysaccharides. Immun Inflamm Dis.

Sunagawa Y et. al. (September 2021). Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy. Clin Epigenetics. 13(1):172.

Zhang Y et. al. (September 2021). Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life. Reprod Toxicol. 105:198-210.

You J. H. et. al. (August 2021). PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells Journal of Experimental & Clinical Cancer Research.

Pizzicannella J et. al. (August 2021). Role of ascorbic acid in the regulation of epigenetic processes induced by Porphyromonas gingivalis in endothelial-committed oral stem cells. Histochem Cell Biol.

Huang P et. al. (July 2021). MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation. Plant J.

Liu et. al. (July 2021). Acute hypoxia effects on Keap1/Nrf2 (Mafs)-GST pathway related oxidative metabolism in muscle of Japanese flounder (Paralichthys olivaceus) Sci Total Environ.

Zhang D et. al. (May 2021). Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Cell Death Dis. 12(6):518.

Hu Y et. al. et. al. (May 2021). Effects of 2,4-dichlorophenol exposure on zebrafish: Implications for the sex hormone synthesis Aquatic Toxicology. 236

Franzago M et. al. (March 2021). Fat mass and obesity-associated (FTO) gene epigenetic modifications in gestational diabetes: new insights and possible pathophysiological connections. Acta Diabetol.

You JH et. al. (March 2021). Mitochondrial pyruvate carrier 1 regulates ferroptosis in drug-tolerant persister head and neck cancer cells via epithelial-mesenchymal transition. Cancer Lett. 507:40-54.

Han J. et. al. et. al. (February 2021). High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation Journal of Environmental Sciences. 107:160-170.

Guo XM et. al. (February 2021). Circulating Cell-Free DNA Methylation Profiles in the Early Detection of Ovarian Cancer: A Scoping Review of the Literature. Cancers (Basel). 13(4)

Zhang Y et. al. (January 2021). Changes of DNA Methylation Patterns Reveal Epigenetic Modification of Dormancy Release-Related Genes Is Induced by Chilling in Tree Peony. DNA Cell Biol.

Zhang et. al. (November 2020). LKB1 Loss Upregulates ALKBH5 and Contributes to Aggressive Phenotypes of KRAS Mutated Lung Cancer Research Square.

Golshan M et. al. (November 2020). Metformin modulates oncogenic expression of HOTAIR gene via promoter methylation and reverses epithelial-mesenchymal transition in MDA-MB-231 cells. J Cell Biochem.

Lee J et. al. et. al. (October 2020). Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer Redox Biology. 37

Jian J et. al. (September 2020). Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 10(25):11820-11836.

He X et. al. (August 2020). Expression and Methylation of Dickkopf-1 in the Pathogenesis and Malignant Transformation of Oral Submucous Fibrosis. J Oral Pathol Med.

Li J et. al. (June 2020). Epigenetic memory marks determine epiallele stability at loci targeted by de novo DNA methylation. Nat Plants. 6(6):661-674.

Bhutani et. al. (June 2020). Role of Epigenetics in Modifying Clinical Outcome in CP-CML Patients Treated with Imatinib International Journal of Science and Healthcare Research. 5(2)

Kyono Y et. al. (March 2020). DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain. Dev Biol.

Ue Din Shah N. et. al. (February 2020). Association of promoter methylation of RASSF1A and KRAS mutations in non-small cell lung carcinoma in Kashmiri population (India) Heliyon. 6(2)

Lu Y et. al. et. al. (February 2020). PDLIM5 improves depression-like behavior of prenatal stress offspring rats via methylation in male, but not female Psychoneuroendocrinology.

Ling Y et. al. (February 2020). Triclosan induces zebrafish neurotoxicity by abnormal expression of miR-219 targeting oligodendrocyte differentiation of central nervous system. Arch Toxicol.

Ju Z et. al. (January 2020). Genome-wide methylation and transcriptome of blood neutrophils reveal the roles of DNA methylation in affecting transcription of protein-coding genes and miRNAs in E. coli-infected mastitis cows. BMC Genomics. 21(1):102.

Hirabayashi S et. al. (January 2020). The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness. Anticancer Res. 40(1):201-211.

Yuan C et. al. (December 2019). 2,4-Dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through DNA methylation. Ecotoxicol Environ Saf. 189:110042.

Zhang C et. al. (November 2019). 2,4-Dichlorophenol induces feminization of zebrafish (Danio rerio) via DNA methylation. Sci Total Environ. :135084.

Igarashi H et. al. (November 2019). PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. Clin Transl Oncol.

Su X et. al. (October 2019). Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation. Cell Mol Immunol.

Upadhyaya P et. al. (October 2019). Genetic and epigenetic modifications induced by chemotherapeutic drugs: human amniotic fluid stem cells as an in-vitro model. BMC Med Genomics. 12(1):146.

Jiang Y et. al. (October 2019). PM2.5-induced extensive DNA methylation changes in the heart of zebrafish embryos and the protective effect of folic acid. Environ Pollut. 255(Pt 3):113331.

Fan Z et. al. (September 2019). Roles of forkhead box protein L2 (foxl2) during gonad differentiation and maintenance in a fish, the olive flounder (Paralichthys olivaceus). Reprod Fertil Dev.

Chen K et. al. (May 2019). Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells. Biotechnol Lett.

Qui Y et. al. (April 2019). Association between methylation of DNA damage response-related genes and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride Chemosphere. 227:323-328.

Wang X et. al. (April 2019). Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis. PLoS Genet. 15(4):e1008094.

Izquierdo V et. al. (March 2019). Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring. Int J Mol Sci. 20(5)

Zhao X et. al. (February 2019). The Role of 5-aza-2'-Deoxycytidine on Methylation Status of Xist Gene in Different Genders of Buffalo (Bubalus bubalis) Bone Marrow Mesenchymal Stem Cells. Cell Reprogram.

Zhang Z et. al. (February 2019). Non-inflammatory emphysema induced by NO 2 chronic exposure and intervention with demethylation 5-Azacytidine Life Sci.

He F et. al. (January 2019). Integrative methylome and transcriptome analysis of Japanese flounder (Paralichthys olivaceus) skeletal muscle during development bioRxiv.

Lee CH et. al. (January 2019). Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer. Cancers (Basel). 11(1)

Dittharot K et. al. (November 2018). Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells. Planta Med.

Yang DL et. al. (October 2018). Four putative SWI2/SNF2 chromatin remodelers have dual roles in regulating DNA methylation in Arabidopsis. Cell Discov. 4:55.

Wei J et. al. (July 2018). A multi-sequence and habitat-based MRI radiomics signature for preoperative prediction of MGMT promoter methylation in astrocytomas with prognostic implication. Eur Radiol.

Kritika Krishnamurthy et. al. (June 2018). Evaluating NISCH and CDH1 Promoter Hypermethylation in Nonsmokers, Cancer Free Smokers and Lung Cancer Patients: A Case Control Study Indian Journal of Clinical Biochemistry. :43837.

Xu XH et. al. (June 2018). Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer. FASEB J. :fj201700715.

Kint S et. al. (June 2018). Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR. PLoS One. 13(6):e0199091.

Wu S et. al. (June 2018). DNA methylation levels and expression patterns of Smyd1a and Smyd1b genes during Metamorphosis of the Japanese Flounder (Paralichthys olivaceus). Comp Biochem Physiol B Biochem Mol Biol.

Tianwei Lin et. al. (May 2018). The Impact and Mechanism of Methylated Metabotropic Glutamate Receptors 1 and 5 in the Hippocampus on Depression-Like Behavior in Prenatal Stress Offspring Rats JCM. 7(6):117.

Meronard K et. al. (March 2018). Voltammetric Application of Polypyrrole-Modified Microelectrode Array for the Characterization of DNA Methylation in Glutathione S-Transferase Pi 1. Anal Lett. 51(16):2612-2625.

Kim H et. al. (March 2018). UV-Induced DNA Methyltransferase 1 Promotes Hypermethylation of Tissue Inhibitor of Metalloproteinase 2 in the Human Skin Journal of Dermatological Science.

Zeng R et. al. (March 2018). EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. Int J Oncol.

Yadav P et. al. (February 2018). Promoter Methylation of BRCA1, DAPK1 and RASSF1A is Associated with Increased Mortality among Indian Women with Breast Cancer Asian Pac J Cancer Prev. 19(2):443-448.

Daino K et. al. (February 2018). Epigenetic dysregulation of key developmental genes in radiation-induced rat mammary carcinomas. Int J Cancer.

Li YX et. al. (January 2018). SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis. Cancer Sci.

Zhang Y et. al. (January 2018). DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows. Cell Stress Chaperones.

Kajal Nandi et. al. (January 2018). THE CLINICAL SIGNIFICANCE OF RASSF1A AND CDH1 HYPERMETHYLATION IN BREAST CANCER PATIENTS International Journal of Scientific Research. 7(1)

Wang J et. al. (October 2017). The construction of intrahepatic cholangiocarcinoma model in zebrafish. Sci Rep. 7(1):13419.

Wang YY et. al. (October 2017). Epigenetic control of cyp19a1a expression is critical for high temperature induced Nile tilapia masculinization. J Therm Biol. 69:76-84.

Wu Y et. al. (September 2017). The shortening of leukocyte telomere length relates to DNA hypermethylation of LINE-1 in type 2 diabetes mellitus. Oncotarget. 8(43):73964-73973.

Ma EG et. al. (September 2017). Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma. Oncotarget. 8(38):63780-63787.

Haraguchi K et. al. (September 2017). The methylation status and expression of human telomerase reverse transcriptase is significantly high in oral carcinogenesis. APMIS. 125(9):797-807.

Deng JH et. al. (August 2017). Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood. Sci Rep. 7(1):7857.

Fan Z et. al. (June 2017). Significant association of cyp19a promoter methylation with environmental factors and gonadal differentiation in olive flounder Paralichthys olivaceus. Comp Biochem Physiol A Mol Integr Physiol. 208:70-79.

Kumar S et. al. (April 2017). Salt-Induced Tissue-Specific Cytosine Methylation Downregulates Expression of HKT Genes in Contrasting Wheat (Triticum aestivum L.) Genotypes. DNA Cell Biol. 36(4):283-294.

Zhang D et. al. (December 2016). Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts. Nucleic Acids Res.

Ejima-Yamada K et. al. (November 2016). Epstein-Barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated B cell lymphoproliferative disorders. Virchows Arch.

Yang Y et. al. (September 2016). SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis. Nucleic Acids Res.

Jiang Y et. al. (September 2016). Trichloroethylene-Induced DNA Methylation Changes in Male F344 Rat Liver. Chem Res Toxicol.

Sun LX et. al. (August 2016). Global DNA Methylation Changes in Nile Tilapia Gonads during High Temperature-Induced Masculinization. PLoS One. 11(8):e0158483.

Kaur M et. al. (July 2016). Development of a multiplex MethyLight assay for the detection of DAPK1 and SOX1 methylation in epithelial ovarian cancer in a north Indian population. Genes Genet Syst.

Li Y et. al. (July 2016). Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma. J Neurooncol.

Lin L et. al. (June 2016). Epigenetic regulation of reelin expression in multiple myeloma. Hematol Oncol.

Wang X et. al. (May 2016). The cytosolic Fe-S cluster assembly component MET18 is required for the full enzymatic activity of ROS1 in active DNA demethylation. Sci Rep. 6:26443.

Zuberi M et. al. (April 2016). Utility of Serum miR-125b as a Diagnostic and Prognostic Indicator and Its Alliance with a Panel of Tumor Suppressor Genes in Epithelial Ovarian Cancer. PLoS One. 11(4):e0153902.

Li Y et. al. (March 2016). Aberrant Methylation of the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endometriosis. Gynecol Obstet Invest.

Amacher DE et. al. (March 2016). A 2015 survey of established or potential epigenetic biomarkers for the accurate detection of human cancers. Biomarkers. :1-17.

Abel S et. al. (March 2016). Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4(+) Foxp3(+) regulatory T cells Immunology.

Chen C et. al. (March 2016). Epigenetic modification of PKMζ rescues aging-related cognitive impairment. Sci Rep. 6:22096.

Yang DL et. al. (December 2015). Dicer-independent RNA-directed DNA methylation in Arabidopsis. Cell Res.

Li H et. al. (November 2015). Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production. Mol Biosyst.

Wang W et. al. (October 2015). Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL. Oncol Rep.

Felli N et. al. (October 2015). AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression Oncogene.

Wang D et. al. (September 2015). Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation. Free Radic Biol Med.

Shao LW et. al. (September 2015). ATRX loss in adult supratentorial diffuse astrocytomas correlates with p53 over expression and IDH1 mutation and predicts better outcome in p53 accumulated patients. Histol Histopathol. :11664.

Barrett HL et. al. (September 2015). Placental lipase expression in pregnancies complicated by preeclampsia: a case-control study. Reprod Biol Endocrinol. 13(1):100.

Zhang S et. al. (July 2015). The g.-165 T>C Rather than Methylation Is Associated with Semen Motility in Chinese Holstein Bulls by Regulating the Transcriptional Activity of the HIBADH Gene. PLoS One. 10(7):e0127670.

Tatura R et. al. (June 2015). Relevance of Foxp3+ regulatory T cells for early and late phases of murine sepsis. Immunology.

Lei M et. al. (March 2015). Regulatory link between DNA methylation and active demethylation in Arabidopsis. Proc Natl Acad Sci U S A. 112(11):3553-7.

Zhang W et. al. (March 2015). Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer. Mol Med Rep.

Ito M et. al. (February 2015). Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway. Int J Cancer.

Zuberi M et. al. (January 2015). RASSF1 & PTEN promoter hypermethylation influences the outcome in epithelial ovarian Cancer Clini Ovarian Other Gyn Cancer.

Nosho K et. al. (January 2015). Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients. Digestion. 91(1):57-63.

Zheng L et. al. (January 2015). FOXA1 positively regulates gene expression by changing gene methylation status in human breast cancer MCF-7 cells. Int J Clin Exp Pathol. 8(1):96-106.

Arechederra M et. al. (December 2014). p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences. Role in migration and invasion. J Biol Chem.

Erdem B et. al. (October 2014). Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients. Turk J Gastroenterol. 25(5):512-7.

Minning C et. al. (August 2014). Exploring breast carcinogenesis through integrative genomics and epigenomics analyses. Int J Oncol.

Naito T et. al. (August 2014). IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol. 20(29):10050-61.

Yamamuro C et. al. (June 2014). Overproduction of stomatal lineage cells in Arabidopsis mutants defective in active DNA demethylation. Nat Commun. 5:4062.

Zhang DH et. al. (May 2014). High-risk human papillomavirus infection associated with telomere elongation in patients with esophageal squamous cell carcinoma with poor prognosis. Cancer.

Wei D et. al. (May 2014). Increased DNA Methyltransferase 3b (Dnmt3b) -mediated CpG Island Methylation Stimulated by Oxidative Stress Inhibits Expression of a Gene Required for Neural Tube and Neural Crest Development in Diabetic Pregnancy. Diabetes.

Ito M et. al. (April 2014). MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions. Int J Cancer.

Hadoux J et. al. (April 2014). SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma. Int J Cancer.

Basu A et. al. (April 2014). The CpG Island Encompassing the Promoter and First Exon of Human DNMT3L Gene Is a PcG/TrX Response Element (PRE). PLoS One. 9(4):e93561.

Guang W et. al. (February 2014). Genetic regulation of MUC1 expression by Helicobacter pylori in gastric cancer cells. Biochem Biophys Res Commun. 445(1):145-50.

Saheb A et. al. (February 2014). Probing for DNA methylation with a voltammetric DNA detector. Analyst. 139(4):786-92.

Guo F et. al. (February 2014). Alternative splicing, promoter methylation, and functional SNPs of sperm flagella 2 gene in testis and mature spermatozoa of Holstein bulls. Reproduction. 147(2):241-52.

Kehrmann J et. al. (January 2014). Impact of 5-Aza-2`-deoxycytidine and Epigallocatechin-3-gallate for induction of human regulatory T cells. Immunology.

Zhang D et. al. (November 2013). Homocysteine-related hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis. Atherosclerosis. 231(1):173-9.

Wang J et. al. (April 2013). The role of EZH2 and DNA methylation in hMLH1 silencing in epithelial ovarian cancer. Biochem Biophys Res Commun. 433(4):470-6.

Sato A et. al. (February 2013). CCAAT/enhancer-binding protein-α suppresses lung tumor development in mice through the p38α MAP kinase pathway. PLoS One. 8(2):e57013.

Kim WG et. al. (January 2013). Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression. Endocrinology. 154(1):25-35.

Founds SA et. al. (August 2012). Variations in discovery-based preeclampsia candidate genes. Clin Transl Sci. 5(4):333-9.

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Martínez-Macías MI et. al. (February 2012). A DNA 3' phosphatase functions in active DNA demethylation in Arabidopsis. Mol Cell. 45(3):357-70.

Yang J et. al. (January 2012). Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases. J Biol Chem. 287(3):1996-2005.

Yang X et. al. (October 2011). Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci. 52(11):8442-54.

Komori HK et. al. (October 2011). Application of microdroplet PCR for large-scale targeted bisulfite sequencing. Genome Res. 21(10):1738-45.

Geyer KK et. al. (August 2011). Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nat Commun. 2:424.

Carrard A et. al. (August 2011). Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J Affect Disord. 132(3):450-3.

Cho YH et. al. (July 2011). Identification of transcriptional regulatory elements required for the Mup2 expression in circadian clock mutant mice. Biochem Biophys Res Commun. 410(4):834-40.

Wang L et. al. (December 1969). Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53. Integr Cancer Ther. 20:15347354211031646.

Choudhari et. al. Matrix Metalloproteinase-9 Gene Polymorphism and Its Methylation in Stroke Patients Malays J Med Sci.. 28(6):32-41.