丁酸钠(Sodium Butyrate)

丁酸钠(Sodium Butyrate)，CAS No：156-54-7，减少细胞内Ca2+的释放。更多视频请关注视频号【艾维缔】。哔哩哔哩【IVDSHOW】。抖音【军哥聊表观】。

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抑制剂

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T1393

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Sodium butanoate (Sodium Butyrate) 是 butyrate 的钠盐。Butyrate 是一种短链脂肪酸，一种 I 类和 II 类组蛋白脱乙酰酶 (HDAC) 的抑制剂，与锌位点竞争性结合。Sodium butanoate 具有潜在抗肿瘤活性。

生物活性

产品描述	Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate, a short-chain fatty acid, an inhibitor of class I and II histone deacetylases (HDAC), which binds competitively to the zinc site. Sodium butanoate has potential antitumor activity.
靶点活性	MCF-7 cells proliferation:5.23 mM, HDAC7:0.3 mM, MDA-MB-231 cells proliferation:5.06 mM, HDAC2:0.4 mM, HDAC1:0.3 mM, T98G cells proliferation:22.7 mM, LN-405 cells proliferation:26 mM
体外活性	方法：NPC 细胞系 5-8F 和 6-10B 用 Sodium butanoate (1-10 mM) 处理 24-72 h，使用 MTT assay 检测细胞活力。结果：在低浓度 (1 mM) 和短暴露时间 (24 h) 下，空白组和 Sodium butanoate 处理组之间的细胞活力没有显著差异。然而，Sodium butanoateu 对 5-8F 和 6-10B 细胞的细胞毒性随着浓度的升高和暴露时间的延长而增加。[1] 方法：人胶质母细胞瘤细胞 A172 用 Sodium butanoate (2 mM) 处理 6-48 h，使用 Western Blot 检测靶点蛋白表达水平。结果：用 Sodium butanoate 处理的 A172 细胞表现出 p21、p27 和 p53 水平的升高，并且这种表达的增加是时间依赖性的。[2]
体内活性	方法：为研究对亨廷顿舞蹈症 (HD) 的作用，将 Sodium butanoate (100-10000 mg/kg) 腹腔注射给 R6/2 小鼠，每天一次，持续至死亡。结果：在 R6/2 转基因 HD 小鼠模型中，使用 Sodium butanoate 调节转录的药理学治疗以剂量依赖性方式显著延长了生存期，改善了体重和运动性能，并延缓了神经病理学后遗症。[3]
细胞实验	Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.
别名	丁酸钠, Sodium Butyrate, Butanoic acid sodium salt

化学信息

分子量	110.09
分子式	C₄H₇NaO₂
CAS No.	156-54-7
Smiles	[Na+].CCCC(=O)[O-]
密度	0.987g/cm3

产品组分

内容	型号	规格	储存温度
丁酸钠(Sodium Butyrate)	T1393-01	100mg	-20°C
丁酸钠(Sodium Butyrate)	T1393-02	500mg	-20°C
丁酸钠(Sodium Butyrate)	T1393-03	1g	-20°C
丁酸钠(Sodium Butyrate)	T1393-04	5g	-20°C
丁酸钠(Sodium Butyrate)	T1393-05	10g	-20°C
操作手册	1	1	常温

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保存建议厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。
FAQ
1.Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929.

2.Nakagawa H, et al. Sodium butyrate induces senescence and inhibits the invasiveness of glioblastoma cells. Oncol Lett. 2018 Feb;15(2):1495-1502.

3.Ferrante RJ, et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci. 2003 Oct 15;23(28):9418-27.

4.Davie JR, et al. J Nutr, 2003, 133(7 Suppl), 2485S-2493S.

5.Ferrante RJ, et al. J Neurosci, 2003, 23(28), 9418-9427.

6.Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230

7.Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929

8.Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.

9.Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34

10.Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27

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