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PD-L1 中和抗体，重组人源化单克隆抗体，可识别人PD-L1的胞外结构域并阻断PD-L1与 PD-1 的结合。该抗体已被证实与小鼠PD-L1存在交叉反应，尚未对其他物种进行测试。
Species
Human
Isotype
IgG1κ
Clonality
Monoclonal
Host Species/Expression System
Freestyle 293 cells
Purification
Protein A affinity chromatography from HEK293 supernatants.
Format
Aqueous buffer solution.
Formulation
8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
MW
50 and 25 kDa for the heavy and light chains, respectively (150 kDa).
Endotoxin Level
<1 EU/µg
Specific Activity
IC50 = 11.5 nM (human PD-L1) 1.8 nM (mouse PD-L1)
UniProt #
Q9NZQ7
Tag(s)
None
Stability
Stable for at least 12 months at -80°C.
Assay Conditions
11.5 nM using PD-1:PD-L1[Biotinylated] Inhibitor Screening Assay Kit (型号：CN72003) and human PD-1 and PD-L1. 1.8 nM using mouse PD-L1 and mouse PD- 1[Biotinylated].
Applications
Useful for inhibition of PD1:PD-L1 interactions.
Shipping Temperature
-80°C
Warnings
Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Scientific Category
Immunotherapy
Regulatory Status
Research Use Only
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产品组分
内容
型号
规格 储存温度
抗PD-L1(CD274)中和抗体
71213-01 100µg -20°C 抗PD-L1(CD274)中和抗体
71213-02 200µg -20°C 操作手册
1 1 常温
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营销中心
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注意事项
保存建议 厂家推荐蓝冰运输。当您收到产品后，按照说明书建议保存于-20°C。 -
FAQ
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Date: 2026 Mar 23 Journal: Cell death & disease Authors: Bhoumick A, Ghosh A, Singh A, Mandal S, Agarwal T, Halder R, Das B, Mukhopadhyay S, Sen P
Teriflunomide modulates the PD-1/PD-L1 axis and enhances antitumor immunity in colorectal cancer.
Date: 2026 Mar 18 Journal: Oncogenesis Authors: Han JH, Lee EJ, Park YH, Ha JH, Ahmed KR, Choi JG, Chung HS
Date: 2023 Jan 18 Journal: International journal of molecular sciences Authors: Lee EJ, Yang JH, Yang HJ, Cho CK, Choi JG, Chung HS
Date: 2020 Journal: Frontiers in immunology Authors: Choi JG, Kim YS, Kim JH, Kim TI, Li W, Oh TW, Jeon CH, Kim SJ, Chung HS
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors.
Date: 2020 Nov 9 Journal: Scientific reports Authors: Zaslavsky AB, Adams MP, Cao X, Maj T, Choi JE, Stangl-Kremser J, Patel S, Putelo A, Lee SK, Nallandhighal S, Kasputis A, Alva A, Lew M, Qin A, Mehra R, Morgan TM, Salami SS, Reichert Z, Udager A, Zou W, Palapattu GS
Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro.
Date: 2020 May 3 Journal: International journal of molecular sciences Authors: Kim JH, Kim YS, Choi JG, Li W, Lee EJ, Park JW, Song J, Chung HS
Date: 2018 Oct 5 Journal: The Journal of biological chemistry Authors: Zou Y, Uddin MM, Padmanabhan S, Zhu Y, Bu P, Vancura A, Vancurova I
Date: 2017 Journal: PloS one Authors: Minchom A, Thavasu P, Ahmad Z, Stewart A, Georgiou A, O'Brien MER, Popat S, Bhosle J, Yap TA, de Bono J, Banerji U
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